The reference to Christian blood emanates from a tweet that Owens liked last week that accused Rabbi Shmuley of being 'drunk on Christian blood.'
'I felt that since Candace got fired on Friday, I may as well try and bring her some Purim cheer by validating all her views about Jews, at least for one day,' he added.
He is also holding a small child in the video, writing: 'This is not a Christian child, this is a Jewish child.'
Rabbi Shmuley then again referenced Candace's previous liking of a post about Christian blood.
'But if it would be, I've got my 'Christian blood,' he continued as he pretended to sip a drink of 'Christian blood' from a red drink container. 'Mmm, spicy, delicious. I've got my Jewish nose. I have 'filth,' he said, noting that the word was written across his forehead.
'Purim is a day when our enemies fall, my brothers and sisters,' he finished.
'If this is the way they want us to look, I'll do it for one night. I'll indulge them.'
Owens publicly responded to the video by quote-tweeting a reply to fellow right-wing commentator Alex Jones, who accused Rabbi Shmuley of 'having a nervous breakdown.'
Owens also reacted on Friday morning after the Anti-Defamation League issued a statement deeming her an anti-Semite.
She wrote on X: 'I am grateful they have turned their smear merchant guns on me. The world already knows my heart. Their attacks will have the opposite desired effect. Awaken world.
'Thank you, @adl'
She continued: 'My crime, is that I do not believe that American taxpayers should have to pay for Israel’s wars or the wars of any other country.
'I will not change my mind. So the question is what will you do to me next? The world is watching.'
Owens' comments came after the ADL posted about white supremacist and Nick Fuentes praising some of the conservative commentator's comments.
'When bigoted people come together to push an anti-Semitic agenda, it adds fuel to the fire of hate,' the ADL said.
Boteach has repeatedly gone against Owens over her anti-Semitic claims that there 'rings' of 'sinister' Jews controlling Hollywood and Washington DC.
Owens has made the shocking false claims that these groups could be behind the death of Michael Jackson. She has also liked posts that claim Jews drink Christian blood ritualistically.
TDW has previously resisted calls to fire Owens, claiming she was exercising free speech and had not violated the law or the terms of her contract.'